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    Glucophage (immediate-release) and extended-release versions like Glucophage XR or Glumetza differ in dosing frequency. Immediate-release tablets are taken twice daily, while extended-release formulations require once-daily administration. Other alternatives, such as metformin SR or generic metformin, vary in release mechanisms but share the same blood sugar-lowering effects. For budget-friendly options, search for metformin 1000 mg ER online or low-cost Glucophage substitutes.

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